專家信息：

江賜忠，男，1974年生，福建人，長聘教授，二級教授，博士生導師，國家重大科學研究計劃首席科學家，同濟大學生物信息系特聘教授，同濟大學轉化醫學高等研究院教授，課題組組長。

南開大學學士與碩士，美國愛荷華州立大學（Iowa State University）遺傳學博士。畢業后先后在美國冷泉港實驗室、弗吉尼亞聯邦大學、賓夕法尼亞州立大學從事博士后研究。主要研究早期胚胎發育、細胞命運決定與轉變、癌癥發生發展過程中的表觀遺傳調控機制。在Nature、Cell Stem Cell、Cell Research、PNAS、Genome Biology、Dev Cell、Adv Sci等期刊發表SCI論文110余篇。主持國家重大科學研究計劃項目、國家自然科學基金重大研究計劃項目與面上項目10余項。先后獲得教育部“新世紀優秀人才”、上海市“浦江人才”、“曙光人才”、“東方學者”特聘教授項目資助。

教育及工作經歷：

1995年，畢業于天津南開大學，獲學士學位。

1998年，畢業于天津南開大學，獲碩士學位

2004年，畢業于美國愛荷華州州立大學，獲遺傳學博士學位，并輔修生物信 息學和計算機科學。

畢業后先后在美國冷泉港實驗室、弗吉尼亞聯邦大學、賓夕法尼亞州州立大學進行博士后研究。

2009年，應聘為同濟大學特聘教授。

學術兼職：

1、上海市遺傳學會理事。

2、廣東省高性能計算學會常務理事。

3、上海市實驗醫學研究院分子診斷創新技術研究所人工智能與大數據技術中心主任。

4、中國抗癌協會腫瘤標志專業委員會委員。

研究領域：

基因在時空上的精確表達受各種表觀遺傳因素的調控�；�因表達差異導致不同的表型，如高矮胖瘦、健康與生病。目前研究較多的表觀遺傳因素有DNA甲基化、組蛋白修飾、核小體定位、染色質高級結構、非編碼RNA、RNA修飾與編輯等。我們課題組聚焦前四種表觀四會因素在早期胚胎發育、細胞命運決定、重大疾病中的表觀遺傳調控機制。

一、早期胚胎發育中的表觀遺傳調控機制

精卵結合經過卵裂、增殖、分化，形成形態各一功能迥異的不同細胞。這些細胞組合形成組織，多種組織再進一步形成器官，最后形成一個個體。透過現象看本質，這些形態各一功能迥異的細胞都來自一個受精卵，擁有相同的一套基因。但在胚胎發育過程中，相同的一套基因受到精確的表觀遺傳調控，在時空上表達不同，從而形成形態各一功能迥異的不同組織細胞。在早期胚胎發育中，最初由卵子中帶來的RNA與蛋白支撐受精卵發育，很快過渡到由合子基因組啟動自身轉錄表達來支撐受精卵后續的發育，這一過程叫合子基因組啟動（也叫母源到合子轉變），它對早期胚胎發育至關重要，也受到精確的表觀遺傳調控。此外，在整個胚胎發育過程中，表觀遺傳基因調控出現異常，重則導致胚胎發育停滯，輕則導致出生缺陷，給社會與個人家庭帶來極大負擔與痛苦。我們通過正常受精與體細胞核移植的小鼠早期發育各階段胚胎，利用多組學技術，通過生物信息學分析與實驗驗證，研究早期胚胎發育過程中的表觀修飾圖譜變化，鑒定關鍵蛋白因子，并探索其對早期胚胎發育的表觀遺傳調控機制。研究成果對理解和預防發育異常相關疾病有重大意義，在輔助生殖、畜牧業中優良品種及瀕危物種的保種育種有重要應用價值。

二、細胞命運決定與轉變中的表觀遺傳調控機制

胚胎干細胞具有全能性，能分化成生物體的各種細胞。反之，經過體細胞重編程，可把已分化的體細胞誘導成具有全/多能性干細胞。另外，對少數類型細胞，通過轉分化技術，可直接把一種類型體細胞轉變成另一種類型體細胞，即細胞轉分化。在上述細胞命運決定與轉變過程中，表觀遺傳調控發揮重要作用。我們課題組利用成熟的體外細胞分化平臺、體細胞重編程技術與轉分化技術，用二代測序技術測定不同階段的基因表達、各種表觀修飾、關鍵轉錄因子全基因組結合位點，通過生物信息學分析與實驗驗證，探索細胞命運決定與轉變中的表觀遺傳調控機制。研究成果為高效獲得高質量的干細胞、前體細胞、特定分化細胞提供理論依據與技術支撐，促進干細胞在基礎研究與臨床治療中的應用。

三、癌癥發生、發展、轉移與耐藥的表觀遺傳調控作用及機制

大量研究表明，許多重大疾病如癌癥、老年癡呆等神經退行性疾病都與表觀遺傳基因調控紊亂有密切關系。癌癥是最難治療的疾病之一，嚴重危害人類健康。癌癥之所以難治療，是其具有轉移與耐藥的特性。二者皆與表觀遺傳調控有密切關系。我們課題組通過體外細胞水平、小鼠體內、與臨床樣本三個層次，探究癌癥干細胞干性維持、癌細胞轉移與耐藥的表觀遺傳調控機制，鑒定關鍵蛋白因子與基因組位點，作為潛在的治療與藥物靶點。研究成果可改善我們對癌癥發生、發展、轉移與耐藥調控機制的理解，最終促進臨床上對癌癥的診斷與治療。

研究方向：

(1) 早期胚胎發育中的表觀遺傳調控機制；

(2) 細胞命運決定與轉變中的表觀遺傳調控機制；

(3) 癌癥發生、發展、轉移與耐藥的表觀遺傳調控作用及機制

承擔科研項目情況：

主持參與了國家“973”重大科學研究計劃項目、國家自然基金委重大研究計劃與面上項目。

1.“973”重大科學研究計劃項目“胚胎發育中的核小體重排與染色質重塑”。 

科研成果：

1. 鑒定、測序和注釋了200多個Myb基因，并存入NCBI數據庫作為共享資源。

2. 收集整合了哺乳動物中（人、小鼠、大鼠）36個與癌癥關聯的轉錄因子家族的成員蛋白因子，并鑒定到這些蛋白因子的共11660個目標基因，識別和標注出這些基因的啟動子，以此為基礎，構建與癌癥關聯的基因調控網絡，成為癌癥研究中的重要資源。

3. 通過單核苷酸多態性分析，證實哺乳動物CpG島的丟失是由于新的DNA甲基化從島的邊緣開始，慢慢向島中央“腐蝕”造成的。這一CpG島丟失機制的證實將極大促進我們對癌癥中DNA甲基化這一表觀遺傳學現象的了解，為設計和研發脫甲基化藥物重新激活被沉默的基因作為治療與DNA甲基化關聯的癌癥的一個手段打下基礎。

4. 近年來利用染色質免疫沉淀結合高通量測序技術，首次在酵母和果蠅中繪制出高分辨率全基因組核小體圖譜，并分析核小體定位對基因轉錄的調控機制等。設計開發了預測、分析核小體及其它蛋白的DNA結合ChIP-seq數據的軟件GeneTrack。

5. 江賜忠教授的研究結果發表在Nature、Nat Rev Genet、Genome Research等國際著名學術刊物上，共發表20篇學術論文，并撰寫專業書的一個章節。以第一作者發表的論文總影響因子超過103，以非第一作者發表的論文總影響因子超過59。其中，果蠅核小體圖譜繪制與基因調控方面的研究成果以Article形式于2008年發表在Nature上，目前單篇引用已超過252次。同年在Genome Research上發表的關于酵母核小體與基因調控方面的研究報道，已被引用211次。2009年在Nature Reviews Genetics上發表了一篇關于核小體定位和基因調控的綜述文章（作為該期封面文章），已被引用223次。2009年10月在Genome Biology上發表的酵母核小體系統參考圖被評為“highly accessed”的文章。值得一提的是，發表在Nature和Genome Research上的兩篇文章同時被國際著名學術期刊Nature Methods以“Research Highlights”形式進行報道；發表在Nature Reviews Genetics上的文章被國際著名學術期刊Nature Reviews Genetics以“Research Highlights”形式進行報道。 

代表性論文：

1.Liu W, Cui X, Zhang Y, Gu L, He Y, Li J, Gao S,3 Gao R#, Jiang C#. (2024) Transcriptome Dynamics and Cell Dialogs Between Oocytes and Granulosa Cells in Mouse Follicle Development. Genom Proteom Bioinf. 2024. Jul 2; 22(2):qzad001. doi: 10.1093/gpbjnl/qzad001. 

2.Gao R*#, Yang G*, Wang M*, Xiao J*, Yi S, Huang Y, Guo Z, Kang Y, Fu Q, Wang M, Xu B, Shen S, Zhu Q, Liu M, Wang L, Cui X, Yi S, Kou X, Zhao Y, Gu L, Wang H, Gao S#, Jiang C#, Chen J#. (2024) Defining a TFAP2C-centered transcription factor network during murine peri-implantation. Dev Cell. 2024 May 6; 59(9):1146-1158.e6. doi: 10.1016/j.devcel.2024.03.015. Epub 2024 Apr 3. 

3.Zheng W*, Wang L*, He W, Hu X, Zhu Q, Gu L#, Jiang C#. (2023) Transcriptome profiles and chromatin states in mouse androgenetic haploid embryonic stem cells. Cell Prolif. 2023 Sep; 56(9):e13436. doi: 10.1111/cpr.13436. Epub 2023 Mar 1. 

4.Wu C*, Liu Y*, Liu W*, Zou T*, Lu S, Zhu C, He L, Chen J, Fang L, Zou L, Wang P, Fan L, Wang H, You H, Chen J#, Fang JY#, Jiang C#, Shi Y#. (2023) NNMT-DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition. Adv Sci (Weinh). 2022 Nov 16;10(1):e2202642. doi: 10.1002/advs.202202642. 

5.Wang, Mingzhu, Zhao, Kun, Liu, Meng, Wang, Mengting, Qiao, Zhibin, ..., Jiang, Cizhong, Gao, Shaorong, Chen, Jiayu (2022). BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding. PROTEIN & CELL.

6.Bai, Dandan, Sun, Jin, Chen, Chuan, Jia, Yanping, Li, Yanhe, ..., Wang, Hong, Wang, Zheng, Chen, Miaoxin (2022). Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos. CELL REPORTS.

7.Liu M*, Guo G*, Qian P*, Mu J*, Lu B, He X, Fan Y, Shang X, Yang G, Shen S, Liu W, Wang L, Gu L, Mu Q, Yu X, Zhao Y, Culleton R, Cao J, Jiang L, Wellems TE#, Yuan J#, Jiang C#, Zhang Q#. (2022) 5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2110713119. doi: 10.1073/pnas.2110713119.

8.Lu, Binbin, Liu, Meng, Gu, Liang, Li, Ying, Shen, Shijun, ..., Culleton, Richard, Wei, Gang, Zhang, Qingfeng (2021). The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum.. mBio.

9.Liu, Wenju, Shen, Junwei, Li, Yanfei, Wu, Jiawen, Luo, Xiaoli, ..., Zhang, Xiaobai, Jiang, Cizhong, Li, Jue (2021). Pyroptosis inhibition improves the symptom of acute myocardial infarction. CELL DEATH & DISEASE.

10.Zhao, Yuemeng, Wang, Fei, Wang, Changhong, Zhang, Xiaobai, Jiang, Cizhong, Ding, Feng, Shen, Li, Zhang, Qingfeng (2021). Optimization of CRISPR/Cas System for Improving Genome Editing Efficiency in Plasmodium falciparum. FRONTIERS IN MICROBIOLOGY.

11.Xu, Xiangjie, Du, Yanhua, Ma, Lin, Zhang, Shuwei, Shi, Lei, ..., Jiang, Cizhong, Liu, Ling, Zhang, Xiaoqing (2021). Mapping germ-layer specification preventing genes in hPSCs via genome-scale CRISPR screening. ISCIENCE.

12.Chen, Wen, Liu, Nana, Shen, Shijun, Zhu, Wei, Qiao, Jing, ..., Xi, Jiajie, Jiang, Cizhong, Kang, Jiuhong (2021). Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring. CELL REPORTS.

13.Yang G*, Zhang L*, Liu W*, Qiao Z, Shen S, Zhu Q, Gao R, Wang M, Wang M, Li C, Liu M, Sun J, Wang L, Liu W, Cui X, Zhao K, Zang R, Chen M, Liang Z, Wang L, Kou X, Zhao Y, Wang H, Wang Y, Gao S#, Chen J#, Jiang C#. (2021) Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer. Cell Stem Cell. 2021 Jan 7; 28(1):150-163. doi: 10.1016/j.stem.2020.09.006.  

14.Sun, Jin, Zheng, Weisheng, Liu, Wenqiang, Kou, Xiaochen, Zhao, Yanhong, ..., Gao, Rui, Gao, Shaorong, Jiang, Cizhong (2021). Differential Transcriptomes and Methylomes of Trophoblast Stem Cells From Naturally-Fertilized and Somatic Cell Nuclear-Transferred Embryos. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.

15.Ma, Lin, Du, Yanhua, Hui, Yi, Li, Nan, Fan, Beibei, ..., Jiang, Cizhong, Liu, Ling, Zhang, Xiaoqing (2021). Developmental programming and lineage branching of early human telencephalon. EMBO JOURNAL.

16.Lu, Ping, Yang, Guang, Jiang, Lichun, He, Wen, Wu, Wanwan, ..., Jiang, Cizhong, Fan, Guoping, Zhu, Xianmin (2021). Characterizing disease progression of nonalcoholic steatohepatitis in Leptin-deficient rats by integrated transcriptome analysis. EXPERIMENTAL BIOLOGY AND MEDICINE.

17.Nagy, Zsuzsanna, Seneviratne, Janith A., Kanikevich, Maxwell, Chang, William, Mayoh, Chelsea, ..., Parker, Michael W., Cheung, Belamy B., Marshall, Glenn M. (2021). An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability. NATURE COMMUNICATIONS.

18.Shang, Xiaomin, Shen, Shijun, Tang, Jianxia, He, Xiaoqin, Zhao, Yuemeng, ..., Cao, Jun, Gu, Liang, Zhang, Qingfeng (2021). A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum. NUCLEIC ACIDS RESEARCH.

19.Guo, Gangqiang, Chen, Aqiong, Ye, Lele, Wang, Huijing, Chen, Zhiyuan, ..., Ding, Xiaokai, Xue, Xiangyang, Zhang, Huidi (2020). TCONS_00483150 as a novel diagnostic biomarker of systemic lupus erythematosus. EPIGENOMICS.

20.Fan, Yanting, Shen, Shijun, Wei, Guiying, Tang, Jianxia, Zhao, Yuemeng, ..., Cao, Jun, Jiang, Cizhong, Zhang, Qingfeng (2020). Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites. MBIO.

21.Fang, Yixuan, Gu, Yue, Li, Lei, Zhu, Lingjiang, Qian, Jiawei, ..., Xu, Youjia, Jiang, Cizhong, Wang, Jianrong (2020). Loss of Atg77 causes chaotic nucleosome assembly of mouse bone marrow CD11b(+)Ly6G(-) myeloid cells. AGING-US.

22.Bai, Dandan, Sun, Jin, Jia, Yanping, Yin, Jiqing, Zhang, Yalin, ..., Teng, Xiaoming, Liu, Wenqiang, Gao, Shaorong (2020). Genome transfer for the prevention of female infertility caused by maternal gene mutation. JOURNAL OF GENETICS AND GENOMICS.

23.Chen, Mo, Zhu, Qianshu, Li, Chong, Kou, Xiaochen, Zhao, Yanhong, ..., Liu, Xiaoyu, Jiang, Cizhong, Cd, Shaorong Gao (2020). Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos.Nat Commun. 2020 Apr 14; 11(1):1813. doi: 10.1038/s41467-020-15607-z.

24.Song, Ya-Xiang, Fan, Shu-Ling, Peng, Ai, Shen, Shijun, Cheng, Jia-Fen, ..., Jiang, Cizhong, Li, Xin-Hua, Liu, Jun-Yan (2020). A retrospective analysis reveals a predictor of survival for the patient with paraquat intoxication. CLINICA CHIMICA ACTA.

25.Zhang, Shiping, Guo, Xiaowei, Wu, Honggui, Sun, Ying, Ma, Xianjue, ..., Ho, Margaret S., Lv, Zhongwei, Xue, Lei (2019). Wingless modulates activator protein-1-mediated tumor invasion. ONCOGENE.

26.Liu, Meng, Lu, Binbin, Fan, Yanting, He, Xiaohui, Shen, Shijun, Jiang, Cizhong, Zhang, Qingfeng (2019). TRIBE Uncovers the Role of Dis3 in Shaping the Dynamic Transcriptome in Malaria Parasites. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.

27.Hu, Xinjie, Zheng, Weisheng, Zhu, Qianshu, Gu, Liang, Du, Yanhua, ..., Cheung, Belamy B., Qiu, Andong, Jiang, Cizhong (2019). Increase in DNA Damage by MYCN Knockdown Through Regulating Nucleosome Organization and Chromatin State in Neuroblastoma. FRONTIERS IN GENETICS.

28.Chen, Kaiming, Li, Dong, Li, Hongwen, Li, Bing, Wang, Ruiqin, ..., Jiang, Cizhong, Gu, Hua, Fang, Jianmin (2019). Improved recombinant protein production by regulation of transcription and protein transport in Chinese hamster ovary cells. BIOTECHNOLOGY LETTERS.

29.Chen, Xiaolong, Ye, Youqiong, Gu, Liang, Sun, Jin, Du, Yanhua, ..., Li, Wei, Zhang, Xiaobai, Jiang, Cizhong (2019). H3K27me3 Signal in the Cis Regulatory Elements Reveals the Differentiation Potential of Progenitors During Drosophila Neuroglial Development.Genom Proteom Bioinf. 2019 Jun; 17(3):297-304. doi: 10.1016/j.gpb.2018.12.009.

30.Li, Jin, Li, Yan, Li, Wei, Luo, Huaibing, Xi, Yanping, Jiang, Ci-zhong..., Peng, Shaoliang, Wu, Feizhen, Yu, Wenqiang (2019). Guide Positioning Sequencing identifies aberrant DNA methylation patterns that alter cell identity and tumor-immune surveillance networks. GENOME RESEARCH.

31.Zhang, Qitong, Zhang, Qingquan, Jiang, Xue, Ye, Youqiong, Liao, Huimin, Jiang, Ci-zhong..., Chen, Yihan, Liang, Xingqun, Sun, Yunfu (2019). Collaborative ISL1/GATA3 interaction in controlling neuroblastoma oncogenic pathways overlapping with but distinct from MYCN. THERANOSTICS.

32.Tang, Wei, Guo, Ren, Shen, Shi-jun, Zheng, Yang, Lu, Yu-ting, ..., Cui, Xue, Jiang, Ci-zhong, Xie, Xin (2019). Chemical cocktails enable hepatic reprogramming of human urine-derived cells with a single transcription factor. ACTA PHARMACOLOGICA SINICA.

33.Nagy, Zsuzsanna, Kanikevichi, Maxwell, Koachi, Jessica, Mayoh, Chelsea, Carter, Daniel, ..., Norris, Murray, Cheung, Belamy, Marshall, Glenn (2019). Alyref is a novel binding partner and co-factor for MYCN-driven oncogenesis in neuroblastoma. CANCER RESEARCH.

34.Chen, Yu, Zhang, Haiping, Xu, Zhu, Tang, Huanyin, Geng, Anke, ..., Jiang, Ying, Gorbunova, Vera, Mao, Zhiyong (2019). A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. NUCLEIC ACIDS RESEARCH.

35.Zhang, Qingquan, Huang, Ru, Ye, Youqiong, Guo, Xiaoxia, Lu, Jun, ..., Jiang, Cizhong, Liang, Xingqun, Sun, Yunfu (2018). Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. CELL DEATH & DISEASE.

36.Zhu, Fugui, Zhu, Qianshu, Ye, Dan, Zhang, Qingquan, Yang, Yiwei, ..., Jiang, Cizhong, Shi, Weiyang, Kang, Jiuhong (2018). Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency. NUCLEIC ACIDS RESEARCH.

37.He, Wenteng, Zhang, Xiaobai, Zhang, Yalin, Zheng, Weisheng, Xiong, Zeyu, ..., Jiang, Cizhong, Gao, Shaorong, Chen, Jiayu (2018). Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b. STEM CELL REPORTS.

38.Ping, Wangfang, Hu, Jian, Hu, Gongcheng, Song, Yawei, Xia, Qing, ..., Gong, Shixin, Jiang, Cizhong, Yao, Hongjie (2018). Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs. CELL DEATH & DISEASE.

39.Hu, Jian, Gu, Liang, Ye, Youqiong, Zheng, Meizhu, Xu, Zhu, ..., Zhang, Xiaobai, Weng, Zhiping, Jiang, Cizhong (2018). Dynamic placement of the linker histone H1 associated with nucleosome arrangement and gene transcription in early Drosophila embryonic development. CELL DEATH & DISEASE.

40.Fu, Shaliu, Wang, Qin, Moore, Jill E., Purcaro, Michael J., Pratt, Henry E., Jiang, Ci-zhong..., Kundaje, Anshul, Lu, Aiping, Weng, Zhiping (2018). Differential analysis of chromatin accessibility and histone modifications for predicting mouse developmental enhancers. NUCLEIC ACIDS RESEARCH.

41.Li, Jingyi, Shen, Shijun, Chen, Jiayu, Liu, Wenqiang, Li, Xiaocui, ..., Yin, Jiqing, Jiang, Cizhong, Gao, Shaorong (2018). Accurate annotation of accessible chromatin in mouse and human primordial germ cells. CELL RESEARCH 2018 Nov;28(11):1077-1089. doi: 10.1038/s41422-018-0096-5.

42.Zhang, Qingquan, Huang, Ru, Guo, Xiaoxia, Ye, Youqiong, Lu, Jun, ..., Jiang, Cizhong, Liang, Xingqun, Sun, Yunfu (2017). The temporal requirements for Isl1 in sympathetic neuron proliferation, differentiation and diversification. MECHANISMS OF DEVELOPMENT.

43.Fang, Yujiang, Liu, Zhongliang, Chen, Zhenyu, Xu, Xiangjie, Xiao, Mengtao, ..., Xiang, Bin, Liu, Ling, Zhang, Xiaoqing (2017). Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis. CELL RESEARCH.

44.Du, Yanhua, Liu, Zhenping, Cao, Xinkai, Chen, Xiaolong, Chen, Zhenyu, Zhang, Xiaobai, Zhang, Xiaoqing, Jiang, Cizhong (2017). Nucleosome eviction along with H3K9ac deposition enhances Sox2 binding during human neuroectodermal commitment. CELL DEATH AND DIFFERENTIATION. 2017 Jun; 24(6):1121-1131.

45.Chen, Kaiming, Li, Dong, Li, Hongwen, Li, Bing, Li, Jie, ..., Jiang, Cizhong, Gu, Hua, Fang, Jianmin (2017). Genetic analysis of heterogeneous sub-clones in recombinant Chinese hamster ovary cells. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.

46.Ye, Youqiong, Li, Min, Gu, Liang, Chen, Xiaolong, Shi, Jiejun, Zhang, Xiaobai, Jiang, Cizhong (2017). Chromatin remodeling during in vivo neural stem cells differentiating to neurons in early Drosophila embryos. CELL DEATH AND DIFFERENTIATION. 2017 Mar 7; 24(3):409-420.

47.Jiang Cizhong, Gao Shaorong (2017). Chromatin remodeling and its epigenetic regulatory mechanisms in cell fate transition. Chinese Bulletin of Life Sciences.

48.Tee, Andrew E., Liu, Bing, Song, Renhua, Li, Jinyan, Pasquier, Eddy, Jiang, Ci-zhong..., Fletcher, Jamie I., Dinger, Marcel E., Liu, Tao (2016). The long noncoding RNA MALAT1 promotes tumor-driven angiogenesis by up-regulating pro-angiogenic gene expression. ONCOTARGET.

49.Jin, Jiali, Liu, Jian, Chen, Cong, Liu, Zhenping, Jiang, Cong, Jiang, Ci-zhong..., Ge, Xin, Xie, Xin, Wang, Ping (2016). The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. NATURE COMMUNICATIONS.

50.Chi, Liankai, Fan, Beibei, Zhang, Kunshan, Du, Yanhua, Liu, Zhongliang,Jiang, Ci-zhong ..., Gao, Liang, Liu, Ling, Zhang, Xiaoqing (2016). Targeted Differentiation of Regional Ventral Neuroprogenitors and Related Neuronal Subtypes from Human Pluripotent Stem Cells. STEM CELL REPORTS.

51.Liu, Ling, Liu, Xu, Ren, Xudong, Tian, Yue, Chen, Zhenyu,Jiang, Ci-zhong ..., Jin, Guohua, Yang, Xiao, Zhang, Xiaoqing (2016). Smad2 and Smad3 have differential sensitivity in relaying TGF beta signaling and inversely regulate early lineage specification. SCIENTIFIC REPORTS.

52.Li, Dong, Shi, Jiejun, Du, Yanhua, Chen, Kaiming, Liu, Zhenping, ..., Gu, Hua, Jiang, Cizhong, Fang, Jianmin (2016). Profiling Analysis of Histone Modifications and Gene Expression in Lewis Lung Carcinoma Murine Cells Resistant to Anti-VEGF Treatment. PLOS ONE.

53.Wo, Da, Peng, Jinhui, Ren, Dan-ni, Qiu, Liman, Chen, Jinxiao, ..., Zou, Yunzeng, Qian, Qirong, Zhu, Weidong (2016). Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and beta-catenin. CIRCULATION.

54.Yang, Yuanyuan, Zhang, Xiaobai, Yi, Li, Hou, Zhenzhen, Chen, Jiayu, ..., Jiang, Cizhong, Wang, Yixuan, Gao, Shaorong (2016). Naive Induced Pluripotent Stem Cells Generated From beta-Thalassemia Fibroblasts Allow Efficient Gene Correction With CRISPR/Cas9 (vol 5, pg 8, 2016). STEM CELLS TRANSLATIONAL MEDICINE.

55.Gao, Hua, Chakraborty, Goutam, Zhang, Zhanguo, Akalay, Intissar, Gadiya, Mayur, Jiang, Ci-zhong..., Brogi, Edi, Leitinger, Birgit, Giancotti, Filippo G. (2016). Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling. CELL.

56.Lu, Ping, Chen, Xiaolong, Feng, Yun, Zeng, Qiao, Jiang, Cizhong, Zhu, Xianmin, Fan, Guoping, Xue, Zhigang (2016). Integrated transcriptome analysis of human iPS cells derived from a fragile X syndrome patient during neuronal differentiation. SCIENCE CHINA-LIFE SCIENCES.

57.Chen, Jun, Chen, Xiaolong, Li, Min, Liu, Xiaoyu, Gao, Yawei, ..., Wang, Hong, Jiang, Cizhong, Gao, Shaorong (2016). Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming. CELL REPORTS.

58.Li, Hongwen, Chen, Kaiming, Wang, Zhe, Li, Dong, Lin, Jiannan, ..., Jiang, Cizhong, Gu, Hua, Fang, Jianmin (2016). Genetic analysis of the clonal stability of Chinese hamster ovary cells for recombinant protein production. MOLECULAR BIOSYSTEMS.

59.Shi, Jiejun, He, Jiangtu, Lin, Jing, Sun, Xin, Sun, Fenyong, Ou, Chao, Jiang, Cizhong (2016). Distinct response of the hepatic transcriptome to Aflatoxin B-1 induced hepatocellular carcinogenesis and resistance in rats. SCIENTIFIC REPORTS.

60.Zhang, Shiping, Guo, Xiaowei, Chen, Changyan, Chen, Yujun, Li, Jikai, ..., Jiang, Cizhong, Li, Wenzhe, Xue, Lei (2016). dFoxO promotes Wingless signaling in Drosophila. SCIENTIFIC REPORTS.

61.Ye, Youqiong, Gu, Liang, Chen, Xiaolong, Shi, Jiejun, Zhang, Xiaobai, Jiang, Cizhong (2016). Chromatin remodeling during the in vivo glial differentiation in early Drosophila embryos. SCIENTIFIC REPORTS.

62.Liang, Xingqun, Zhang, Qingquan, Cattaneo, Paola, Zhuang, Shaowei, Gong, Xiaohui, Jiang, Ci-zhong..., Chen, Ju, Sun, Yunfu, Evans, Sylvia M. (2015). Transcription factor ISL1 is essential for pacemaker development and function. JOURNAL OF CLINICAL INVESTIGATION.

63.Men, Hewei, Zheng, Weisheng, Li, Junjie, Jiang, Cizhong, Cai, Jinzhen, Li, Jiang, Teng, Dahong (2015). The microRNA Signatures in Mouse Liver Ischemia Reperfusion Injury. TRANSPLANTATION.

64.Shen, Junwei, Jia, Wenwen, Yu, Yangyang, Chen, Jie, Cao, Xinkai, ..., Duan, Tao, Jiang, Cizhong, Kang, Jiuhong (2015). Pwp1 Is Required for the Differentiation Potential of Mouse Embryonic Stem Cells Through Regulating Stat3 Signaling.Stem Cells, 33(3): 661-73

65.Huang, Kaimeng, Zhang, Xiaobai, Shi, Jiejun, Yao, Mingze, Lin, Jiannan, ..., Jiang, Cizhong, Pei, Duanqing, Yao, Hongjie (2015). Dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells. SCIENTIFIC REPORTS.

66.Fu, Yanbin, Huang, Chenwen, Xu, Xinxiu, Gu, Haifeng, Ye, Youqiong, Jiang, Cizhong, Qiu, Zilong, Xie, Xin (2015). Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails. CELL RESEARCH.

67.Li, Dong, Xie, Kun, Ding, Guitao, Li, Jie, Chen, Kaiming, ..., Qian, Jie, Jiang, Cizhong, Fang, Jianmin (2014). Tumor resistance to anti-VEGF therapy through up-regulation of VEGF-C expression.  Cancer Lett., 346(1): 45-52

68.Li, Min, Liu, Zhenping, Gu, Liang, Yin, Rong, Li, Huarong, Zhang, Xiaobai, Cao, Tongcheng, Jiang, Cizhong (2014). Toxic effects of decabromodiphenyl ether (BDE-209) on human embryonic kidney cells. FRONTIERS IN GENETICS.5: 118

69.Hu, Xinyang, Wu, Rongrong, Shehadeh, Lina A., Zhou, Qing, Jiang, Cizhong, ..., Yu, Hong, Webster, Keith A., Wang, Jian'an (2014). Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells.  BMC Genomics, 15(1): 303

70.Lin, Jiannan, Chen, Guangfeng, Gu, Liang, Shen, Yuefeng, Zheng, Meizhu, ..., Qiu, Yu, Liu, Xiaoqing, Jiang, Cizhong (2014). Phylogenetic affinity of tree shrews to Glires is attributed to fast evolution rate. Mol. Phylogenet. Evol., 71: 193-200

71.Tao, Yu, Zheng, Weisheng, Jiang, Yonghua, Ding, Guitao, Hou, Xinfeng, ..., Wang, Hong, Jiang, Cizhong, Gao, Shaorong (2014). Nucleosome organizations in induced pluripotent stem cells reprogrammed from somatic cells belonging to three different germ layers. BMC BIOLOGY. 12(1): 109

72.Yin, Rong, Gu, Liang, Li, Min, Jiang, Cizhong, Cao, Tongcheng, Zhang, Xiaobai (2014). Gene Expression Profiling Analysis of Bisphenol A-Induced Perturbation in Biological Processes in ER-Negative HEK293 Cells.  PLoS One., 9(6): e98635

73.Huang, Biao, Jiang, Cizhong, Zhang, Rongxin (2014). Epigenetics: the language of the cell?.Epigenomics, 6(1): 73-88

74.Shi, Jiejun, Zheng, Meizhu, Ye, Youqiong, Li, Min, Chen, Xiaolong, ..., Sun, Jin, Zhang, Xiaobai, Jiang, Cizhong (2014). Drosophila Brahma complex remodels nucleosome organizations in multiple aspects. Nucleic Acids Res., 42(15): 9730-9

75.Chen, Guangfeng, Shi, Xiujuan, Sun, Chen, Li, Min, Zhou, Qing, ..., Jiang, Cizhong, Ying, Ming, Liu, Xiaoqing (2013). VEGF-Mediated Proliferation of Human Adipose Tissue-Derived Stem Cells. PLoS One, 8(10): e73673

76.Zhang, Xiaobai, Shen, Yuefeng, Ding, Guitao, Tian, Yi, Liu, Zhenping, Li, Bing, Wang, Yun, Jiang, Cizhong (2013). TFPP: An SVM-Based Tool for Recognizing Flagellar Proteins in Trypanosoma brucei.  PLoS One, 8(1): e54032

77.Huang, Kaimeng, Jia, Jinping, Wu, Changwei, Yao, Mingze, Li, Min, Jiang, Ci-zhong..., Pei, Duanqing, Pan, Guangjin, Yao, Hongjie (2013). Ribosomal RNA Gene Transcription Mediated by the Master Genome Regulator Protein CCCTC-binding Factor (CTCF) Is Negatively Regulated by the Condensin Complex. JOURNAL OF BIOLOGICAL CHEMISTRY., 288(36): 26067-77

78.Dai, Xiuqin, Jiang, Weijian, Zhang, Qingquan, Xu, Lian, Geng, Peng, Jiang, Ci-zhong..., Sun, Yunfu, Chen, Ju, Liang, Xingqun (2013). Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis. BMC BIOLOGY.11(1): 107

79.Shi, Jiejun, Hu, Jian, Zhou, Qing, Du, Yanhua, Jiang, Cizhong (2013). PEpiD: A Prostate Epigenetic Database in Mammals. PLoS One, 8(5): e64289

80.Guo, Xudong, Liu, Qidong, Wang, Guiying, Zhu, Songcheng, Gao, Longfei, ..., Liu, Houqi, Jiang, Cizhong, Kang, Jiuhong (2013). microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming. CELL RESEARCH., 23(1): 142-56

81.Tang, Yitao, Dong, Shan, Cao, Xinkai, Zhou, Qing, Ding, Guitao, Jiang, Cizhong (2013). H2A.Z Nucleosome Positioning Has No Impact on Genetic Variation in Drosophila Genome.  PLoS One, 8(3): e58295

82.Chang GS, Noegel AA, Mavrich TN, Müller R, Tomsho L, Ward E, Felder M, Jiang C, Eichinger L, Glockner G, Schuster SC, Pugh BF. (2012) Unusual combinatorial involvement of poly-A/T tracts in organizing genes and chromatin in Dictyostelium. Genome Res, 22(6): 1098-106

83.Bao, Jianqiang, Li, Ding, Wang, Li, Wu, Jingwen, Hu, Yanqin, ..., Jiang, Cizhong, Yan, Wei, Xu, Chen (2012). MicroRNA-449 and MicroRNA-34b/c Function Redundantly in Murine Testes by Targeting E2F Transcription Factor-Retinoblastoma Protein (E2F-pRb) Pathway. Journal of Biological Chemistry, 287(26): 21686-98

84.Venters, Bryan J., Wachi, Shinichiro, Mavrich, Travis N., Andersen, Barbara E., Jena, Peony, ..., Jiang, Cizhong, Hemeryck-Walsh, Christine, Pugh, B. Franklin (2011). A Comprehensive Genomic Binding Map of Gene and Chromatin Regulatory Proteins in Saccharomyces. MOLECULAR CELL, 41(4): 480-92

85.Zhao, Zhongming, Jiang, Cizhong (2010). Features of Recent Codon Evolution: A Comparative Polymorphism-Fixation Study. Journal of Biomedicine and Biotechnology, 2010(2010): doi:10.1155/2010/202918

86.Jiang, Cizhong, Pugh, B. Franklin (2009). Nucleosome positioning and gene regulation: advances through genomics. Nature Reviews Genetics, 10(3): 161-72 Cover story

87.Koerber, R. Thomas, Rhee, Ho Sung, Jiang, Cizhong, Pugh, B. Franklin (2009). Interaction of Transcriptional Regulators with Specific Nucleosomes across the Saccharomyces Genome.  Mol Cell, 35(6): 889-902 

88.Jiang, Cizhong, Pugh, B. Franklin (2009). Identification and Nomenclature of the Consensus Nucleosomes Across the Yeast Genome. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS.

89.Jiang, Cizhong, Pugh, B. Franklin (2009). A compiled and systematic reference map of nucleosome positions across the Saccharomyces cerevisiae genome.  Genome Biology, 10: R109

90.Mavrich, Travis N., Jiang, Cizhong, Ioshikhes, Ilya P., Li, Xiaoyong, Venters, Bryan J., ..., Gilmour, David S., Albert, Istvan, Pugh, B. Franklin (2008). Nucleosome organization in the Drosophila genome. Nature, 453(7193): 358-62 Article

91.Lee, Chanhyo, Li, Xiaoyong, Hechmer, Aaron, Eisen, Michael, Biggin, Mark D., Jiang, Ci-zhong..., Li, Jian, Pugh, B. Franklin, Gilmour, David S. (2008). NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila. MOLECULAR AND CELLULAR BIOLOGY, 28(10): 3290-300

92.Albert, Istvan, Wachi, Shinichiro, Jiang, Cizhong, Pugh, Franklin (2008). GeneTrack - a genomic data processing and visualization framework.  Bioinformatics, 24(10): 1305-6

93.Kuo, Po-Hsiu, Kalsi, Gursharan, Prescott, Carol A., Hodgkinson, Colin A., Goldman, David, Jiang, Ci-zhong..., Walsh, Dermot, Kendler, Kenneth S., Riley, Brien P. (2008). Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. Alcoholism: Clinical and Experimental Research, 32(5): 785-95

94.Mavrich, Travis N., Ioshikhes, Ilya P., Venters, Bryan J., Jiang, Cizhong, Tomsho, Lynn P., ..., Schuster, Stephan C., Albert, Istvan, Pugh, B. Franklin (2008). A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome. Genome Research, 18(7): 1073-1083

95.Zhao, Zhongming, Jiang, Cizhong (2007). Methylation-dependent transition rates are dependent on local sequence lengths and genomic regions. MOLECULAR BIOLOGY AND EVOLUTION, 24(1): 23-5

96.Jiang, Cizhong, Han, Leng, Su, Bing, Li, Wen-Hsiung, Zhao, Zhongming (2007). Features and trend of loss of promoter-associated CpG islands in the human and mouse genomes. MOLECULAR BIOLOGY AND EVOLUTION., 24(9): 1991-2000   

97.Zhao, Z and Jiang, C (2007) Investigation of the CpG Effect in Mammalian Genomes - Chapter I in: Kobayashi TB editor. DNA Methylation Research Trends, Pg 1-24. Nova Science Publishers, Inc., Hauppauge, NY (ISBN 1-60021-721-4)

98.Jiang, C, Xuan, Z, Zhao, F, and Zhang, MQ (2007) TRED: a Transcriptional Regulatory Element Database, new entries and other development. Nucleic Acids Res., 35: D137-D140

99.Jiang, Cizhong, Zhao, Zhongming (2006). Mutational spectrum in the recent human genome inferred by single nucleotide polymorphisms. Genomics, 88(5): 527-34

100.Jiang, Cizhong, Zhao, Zhongming (2006). Directionality of point mutation and 5-methylcytosine deamination rates in the chimpanzee genome. BMC Genomics, 7(1): 316

101.Boddu, J, Jiang, CH, Sangar, V, Olson, T, Peterson, T, Chopra, S (2006). Comparative structural and functional characterization of sorghum and maize duplications containing orthologous myb transcription regulators of 3-deoxyflavonoid biosynthesis. PLANT MOLECULAR BIOLOGY, 60(2): 185-99

102.Seo, Daekwan, Jiang, Cizhong, Zhao, Zhongming (2006). A novel statistical method to estimate the effective SNP size in vertebrate genomes and categorized genomic regions. BMC Genomics, 7(1): 329

103.Jiang, CH, Gu, JY, Chopra, S, Gu, X, Peterson, T (2004). Ordered origin of the typical two- and three-repeat Myb genes. Gene, 326: 13-22

104.Jiang, CZ, Gu, X, Peterson, T (2004). Identification of conserved gene structures and carboxy-terminal motifs in the Myb gene family of Arabidopsis and Oryza sativa L. ssp indica. Genome Biology, 5(7): R46

105.Jiang, CZ, Song, WQ, Li, XL, Chen, RY (1998). Studies on microdissection and microcloning of the rye chromosome 1R. Acta Botanica Sinica, 40(11): 988-993 

榮譽獎勵：

資料更新中……

 

學術交流：

1. 參加了2009年的The 16th Conversation for Journal of Biomolecular Structure and Dynamics國際會議。

2. 參加了2010年的The 8th International Bioinformatics Workshop國際會議。

3. 參加了2010年與2012年冷泉港亞洲會議Epigenetics, Chromatin & Transcription國際會議。

4. 參加了2012年的International Workshop and Summer School on Crops國際會議。

5. 同時也邀請了時為北卡羅來納州大學教堂山分校(University of North Carolina at Chapel Hill)的Jason Lieb教授等國內外知名學者來校訪問交流。