趙保路,男，中國科學院生物物理研究所研究員，博士生導師，中國科學院研究生院教授。1970年畢業于中國科學技術大學，1981年研究生畢業于中國科學院研究生院，獲碩士學位。曾先后在中國科學院生物物理研究所，美國 Ohio State University（1985-1987，1990-1992）和 University of California at Berkeley（1998-1999），英國 Institute of Food Research和香港大學（1996-1997從事研究工作。曾任中國科學院生物物理研究所副所長，主管業務工作。目前擔任亞洲自由基研究學會主席，中國生物物理學會自由基生物學和醫學專業委員會主任，中國衰老和抗衰老生物學委員會副主任，中國物理學會波譜學專業委員會理事，世界中醫藥學會聯合會亞健康專業委員會理事，北京煙草學會常務理事。現為 “Biofactor”,“Journal of Clinical Biochemistry and Nutrition” “生物物理學報”,“波譜學雜志”,“中國老年學雜志”， 和“中國煙草學報”編委。先后完成“細胞膜膜蛋白的生物物理特性研究”，“癌癥中活性氧的分子機理研究”，”香煙中瞬時和穩定有害自由基性質的研究" “巨嗜細胞產生一氧化氮自由基機理和天然抗氧化劑對一氧化氮的調節作用“和“氧自由基誘導神經細胞凋亡和天然抗氧化劑調節作用的分子機理“ 國家自然基金課題及 "氧自由基的代謝失衡和天然抗氧化劑的清除機理"和"氧自由基對細胞膜的損傷效應和天然抗氧化劑的調節機理”“活性自由基生物功能及其機理的ESR成像研究”和“植物抗病感病中一氧化氮自由基的作用機理”、“抗氧化劑預防帕金森癥（PD）的機理研究”、“天然抗氧化劑延緩衰老作用機理”、和“煙堿預防和治療老年退行性疾病研究”兩項科學院和國家自然國家自然科學基金 85重點課題及多項國家基金課題。“腫瘤細胞膜的生物物理特性” 獲 1987年中國科學院科技進步三等獎；“人多形核白細胞呼吸爆發產生的氧自由基和天然抗氧化劑的清除機理” 獲1993年中國科學院自然科學二等獎。1998年“低毒低自由基香煙配方和生產方法”獲中國科學院發明三等獎。先后在國內外核心期刊上發表200多篇研究論文，兩部專著和 五項發明專利。現為國家基金“抗氧化劑通過PPARS延緩衰老的機理研究”，“光動力作用誘導癌細胞凋亡信號轉導調控網絡”和十五重大子課題“用核技術研究汞和稀土的分子毒理機制”項目和開發等項目負責人。和英國帝國理工學院有合作項目，與美國FDA生物物理實驗室，The Salk Institute for biological Studies 神經實驗室有合作項目。與法國Universite Victor Segalen-Bordeaux 2，神經生理實驗室合作研究PD的發病機理和預防措施。同時與北京玄武醫院老年病研究所有合作關系。2005年被美國“The Oxygen Club of California”授予終身會員稱號。

近期發表的主要研究論文：

1. Shen J-G, Guo X-S, Jiang B, Li M, Xin W-J, Zhao B-L: Chinonin, a novel drug against cardiomyocyte apoptosis induced by hypoxia and reoxygenation. Biochim Biophyscs Acta 1500, 217-226,2000.

2. Shen J-Gang, Li M, Xin W-J, Zhao B-L: Effects of Chinonin on nitric oxide free radical, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo. Appl Magn Reson 19-9-19,2000.

3. Xin W-J, Wei T-T, Chen C, Ni Y-C, Zhao B-L: Mechanisms of apoptosis in rat cerebellar granule cells induced by hydroxyl radicals and effects of Egb761 and its constitutes. Txicology 148 103-110,2000.

4. Li, H-T, Hu J-G, Xin W-J, Zhao B-L: Production and interaction of oxygen and nitric oxide free radicals in PMA stimulated macrophages during the respiratory. Redox Report 5，353-358，2000.

5. Gao J-T, Tang H-R, Zhao B-L: The ESR study on the protective effect of grape seed extract on rat heart mitochondria from injury of lipid peroxidation. Res Chem Intermed 26,817-828 2000.

6. Tang H-R, Zhao B-L, Belton P S, Sutchiffe L H, Ng A: Anomalous proton NMR relaxation behavior of cell wall materials from Chinese water chesnut. Magn Reson Chem 38,765-770,2000.

7. Zhao B-L, Zhou W-A, Ni,Y-C, Hou,J-W, Gao,T-L, Xin,W-J: Kinetic scavenging effects of chinonin on NO and oxygen free radicals generated from ischemia reperfusion myocardium and its protection effects on the myocardium. Res Chem Intermed 747-762,2000.

8. Zhao B-L, Guo Q, Xin W-J: Free radical scavenging by green tea polyphenols. Method Enzym 335 217-231,2001

9.  Nie G-J, Wei T-T, Zhao B-L:Polyphenol protection of DNA against damage. Method Enzym 335 232-231244,2001

10. Gao J-T, Tang H-R, Zhao B-L: The toxicological damagement of gas phase cigarette smoke on cells and protective effect of green tea polyphenols. Res Chem Intermed.27,269-280,2001.

11. Zhang D-L, Xiong J, Hu J,Li Y, Zhao B-L: Improved method to detect nitric oxide in biological syste. Appl Magn Reson 20,345-358,2001.

12. Nie GJ, Jin C-F, Cao Y-L, Shen S-R, Zhao B-L: Distinct effects of tea catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells. Arch Biochem Biophys 397,84-90,2002.

13. Nie GJ, Cao YL, Zhao B-L: Protective effects of green tea polyphenols and their major component, (-)-epigallocatechin-3-gallate (EGCG), on 6-hydroxyldopamine-induced apoptosis in PC12 cells. Redox Report,7,170-177,2202.

14. Gao JT, Tang HR, Li Y, Liu H, Zhao B-L: EPR study of the toxicological effects of Gas-phase cigarette smoke and the protective effects of grape seed extract on the mitochondrial membrane. Applied Magnetic Resonance 22,497-511,2002.

15. Zhang Y-T, Zhang D-L, Cao Y-L, Zhao B-L: Developmental experession and activity variation of nitric oxide synthesase in the brain of golden hamster. Brain Res Bulletin 58,385-389,2002.

16. Chen L-J, Yang X-Q, Jiao H-L, Zhao B-L: Tea catechins protect against Lead-induced cytotoxicity, lipid peroxidation, and membrane fluidity in HepG2 Cells. Toxcol Sci 69,149-156,2002.

17. Guangyin Zhou,  Wen Jiang,  Yan Zhao, Guangen Ma，Wenjuan Xin,  Junjie Yin and Baolu Zhao.Interaction between sodium tanshinone IIA sulfonate and the adriamycin semiquinone free radical: A possible mechanism for antagonizing adriamycin-induced cardiotoxity. Res Chem Interm. 28,277-290,2002.

18. Li W, Wei T-T, Xin W-J, Zhao B-L: Green tea polyphenols in combination with copper(II) induce apoptosis in Hela cells. Res Chem Interm. 28,505-618,2002.

19. Jiao H-L, Zhao B-L. Cytotoxic effect of peroxisome proliferator fenofibrate on human HepG2 hepatoma cell line and relevant mechanisms. Toxcol Appl Pharm 185,172-179,2002.

20. Cao Y-L, Niu Y-C, Zhao B-L: Study of effect of NO on wheat stripe rust by ESR. Free Rad Biol Med, 33 ,S74,2002.

21.  Shen J-G, Fung PCW, Xin W-J, Zhao B-L: Nitric oxide contributes to restribution of phosphatidylserine and triggers apoptosis via peroxynitrite and p53 pathway in hypoxia-reoxygenated cardiomyocyte. Free Rad Biol Med, 33 ,S82,2002.

22. Fung PCW, Shen J-G, Xin W-J, Zhao B-L: Gikgo Biloba extract (EGB 761) against  hypoxia-reoxygenated induced cardiomyocyte apoptosis via inhibiting NO/ONOO pathway and adjusting bcl-2,p53 and p21/wal/cip 1 expression_. Free Rad Biol Med, 33 ,S82-83,2002.

23. Nie G-J, Jin C-F, Shen S-R, Zhao B-L: Effect of green tea polyphenols on 6-HODA-induced apoptosis in PC12 cells. Free Rad Biol Med, 33 ,S212,2002.

24. Zhang D-L, Tao Y, Duan S-J, Rohdwald P, Zhao B-L: Pycnogenol in Cigarette Filters Scavenges Free Radicals and Reduces Mutagenicity and Toxicity of Tobacco Smoke In Vivo. Toxicol Indus Health 18,215-224, 2002.

25. Liu Q, Tao Y, Zhao B-L: ESR study on scavenging effect of nicotine on free radicals. Appl Mag Reson. 24,105-112,2003.

26. Zhou G-Y, Jiang w, Zhao Y, Ma G-E, Xin W-J, Yin J, Zhao B-L:Sodium tanshinone IIA sulfonate mediates electron transfer reaction in rat heart mitochondria. Biochem Pharmacol. 65，51-57，2003。

27. Zhao-BL，Antioxidant effects of green tea polyphenols。CHINESE SCI BUL.  48 (4) : 315-319，2003。

28. Shen J-G, Qiu X-S, Jiang B, Zhang D-L, Xin W-J, Fung P.C.W., Zhao B-L: Nitric oxide and oxygen radicals induced apoptosis via bcl-2 and p53 pathway in hypoxia-reoxygenated cardiomyocytes. Sci China. 46,27-39,2003.

29. Deliang Zhang, Zhiyv Niu, Qian Wan, Baolu Zhao： Stability and Reaction of Dithiocarbamate-ferrous-NO Complex in PMA-stimulated Peritoneal Macrophages。Res Chem Interm. 29,201-212,2003.

30.  Zhang Yueting and Zhao Baolu ：Green tea polyphenols enhance sodium nitropru

sside induced neurotoxicity in human neuroblastoma SH-SY5Y cells. J Neur Chem.86,1189-1200,2003.31. Jiao H-L, Ye P, Zhao B-L: Protective effects of green tea polyphenols on human HepG2 cells against oxidative damage of fenofibrate. Free rad Biol Med 35(9)，1121-1128，2003.

32. Chen L-J, Yang X-Q, Jiao H-L, Zhao B-L: Tea Catechins protect against lead-induced ROS formation, mitochondrial dysfunction and calcium dysregulation in PC 12 cells. Chem Res Toxiol 16,1155-1161,2003.

33. Xu Y-C, Zhao B-L: The main origin of endogenous NO in higher non-leguminous plant. Plant Bioph Biochem 41，833－838， 2003.

34. Haiyan Zeng, Qi Chen, Baolu Zhao: Genistein ameliorated β-amyloid peptide -induced hippocampal neuronal apoptosis. Free Rad Biol Med 36,180-188,2004.

35. Liu Q and Zhao B-L: Nicotine attenuates β-amyloid peptide induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures. Brit J. Pharmocol 141，746-754，2004。

36. Guo P, Cao Y-L, Li Z-Q, Zhao B-L: Role of an endogenous nitric oxide burst in the resistance of wheat to stripe rust. Plant Cell Environ. 27 (4), 473-477，2004。

37. Xu Y-C, Cao Y-L, Guo P, Zhao B-L: Detection of nitric oxide in plants by electron spin resonance. Phytopath 94,402-407,2004.

38. Zhang D-L, Yin J-J，Zhao B-L: Oral administration of Crataegus extraction protects against ischemia/reperfusion brain damage in the Mongolian gerbils. J Neur Chem.. 90，211-219, 2004.

39. Chen,LJ Yang XQi, Jiao HL, Zhao BL：Effect of Tea Catechins on the Change of Glutathione Levels Caused by Pb++ in PC12 Cells. Chem Res Toxiol 17，922-928，2004.

40. Zhang J, Wang X-F, Lu Z-B, Liu N-Q, Zhao B-L: The effects of Meso 2, 3-dimercaptosuccinic acid and Olipomeric Procyanidins on acute lead neurotoxicity in rat hippocampus. Free Rad Biol Med 37，1037-1050，2004。

41. Yueting Zhang Jie Zhang and Baolu Zhao：Nitric oxide synthase inhibition prevents neuronal death in the developing visual cortex. Eur J Neurosci 20,2251-2259,2004.

42. Liu HL, Zhang DL, Zhao BL, Zhao JY：Superoxide anion, the main species of ROS in the development of ARDS induced by oleic acid。FREE RADICAL RES 38: 1281-1287，2004。

43. Baolu Zhao: Nitric oxide in neirodegenarative diseases. Front Biosci 10, 454-461, 2005.

44. Baolu Zhao: Natural antioxidant for neurodegenerative diseases. Mol Neurobiol, 31, 283-293，2005

45. Cao Y, Guo P, Zhao B-L Simultaneous detection of NO and ROS by ESR in biological system. Method Enzymol  396,77-83, 2005

46. Xu Y-C, Cao Y-L, Tao Y, Zhao B-L: Technique of detection of NO in plants by ESR spin trapping. Method Enzym  396,84-92, 2005

47. S-H Guo, E Bezard, B-L Zhao：Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway. Free Rad Biol Med 39: 682-695，2005;

48. Yu-Xiang Xie, Erwan Bezard, Bao-Lu. Zhao: Unraveling the receptor- independent neuroprotective mechanism in mitochondria. J. Biol Chem. 37，32405-32412，2005。

49. Astrid Gutierrez-Zepeda, Ross Santell, Zhixin Wu, Marishka Brown, YanJue Wu, Ikhlas Khan, Christopher D Link, Baolu Zhao and Yuan Luo：Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans.BMC Neuroscience. 2005, 6:54，1-9。

50. Wu Ke, Huang Changgang, Cao Yuanlin，Zheng Yingguang，Cong Jianbo, Xian Hong, Wang Changzhen, Gao Shangkai ,Zhao Baolu. Plate form three-dimensional gradient coils for L-band ESR imaging experiment” published in the Journal of Magnetic Resonance, 2005; 175: 256-263.

51. Zhongbin Lu, Guangjun Nie, Peter Belton, Huiru Tang, Baolu Zhao. Structure-activity Relationship Analysis of Antioxidant Ability and Neuroprotective Effect of Gallic Acid Derivatives. Neurochem Int 48,263-274 2006.

52. Baolu Zhao. The health effects of tea polyphenols and their antioxidant mechanism. J. Clinical Biochem. Nutrition, 38 (2006).59-68.

53. Jie Zhang, Qiang Liu Nian-Qing Liu, Fu-Liang Li, Qi Chen, Chuan Qin, Hua Zhu， Yu-Ying Huang, Wei He, Bao-Lu Zhao.Nicotine reduces β-amyloidosis by regulating metal homeostasis. FASEB J 20，1212-1214，2006。

54. Zhang Jie, Mori, Akitane, Zhao Baolu.Fermented papaya preparation attenuates APP:A mediated copper neurotoxicity in APP and APPsw overexpressing SH-SY5Y cells。Neuroscience 143 ，63–72，2006。

55. Zhongbing Lu, Yi Tao, Zhixiang Zhou, Junjing Zhang, Cong Li, Lingcheng OU, Baolu Zhao. Mitochondrial ROS and NO Mediated Cancer Cell Apoptosis in 2-BA-2-DMHB Photodynamic Therapy. Free Rad Biol. Med. 41，1590–1605，2006。

56. Qiang Liu, Jie Zhang, Hua Zhu, Chuan Qin, Qi Chen，Baolu Zhao. Dissecting the Signalling Pathway of Nicotine-Mediated Neuroprotection in a Mouse Alzheimer Disease Model. FASEB J (in press)

57. Guoliang Jie, Zhi Lin, Longze Zhang, Haipeng Lv,  Puming He, Baolu Zhao。Free radical scavenging effect of Pu-erh tea extracts and their protective effect on the oxidative damage in the HPF-1 cells。J Agricu Food Chem （in press，2006）

58.  Baolu Zhao, Gengtao Liu, Lester Packer: Natural antioxidants and micronutrients. Medimond, Editografica. Rastignano.Bologna (Intaly), 2005.

59.  趙保路: 專著“氧自由基和天然抗氧化劑”科學出版社 2002（再版）

專利

1．低自由基低毒卷煙及其生產方法(申請號96116865、7)1995年申請；2001授權批準（專利號95116865.7）

2．一種有效清除卷煙煙氣中自由基的卷煙濾嘴及其制備方法：(申請號00130133.0),2000年申請，2003年授權批準（專利號ZL00130133.0）。

3．國際專利Cigarette filter with scavenging effect on free radicals in cigarette smoke and its preparation method，2004 年授權批準（專利號US 6,832,612,B2）;

4．一種抑制腫瘤生長、清除自由基和抗脂質過氧化的動物軟骨膠囊及其制備方法。1999年申請，2003年授權批準（專利號ZL9910076.0）。

5．一種抗老年癡呆癥復合制劑：(申請號200410042774。7),2004年。

6．一種抗帕金森癥復合制劑：(申請號200410047571。7),2004年。

國際會議特邀報告：

1. “Free radical reaction of green tea polyphenols” In 2000 4th UNESCO-MCBN/COSTAM/SFFR (ASEAN) WORKSHOP Micronutrients and Health: Molecular Biological Mechanisms as invited speaker. Malaysia.

2. “The scavenging effect of antioxidant on NO free radical in ischemia-reperfusion heart and their protective effect” In 2001 The Second International Symposium on Natural Antioxidants. Beijing, China. 大會主席:劉耕陶。

3. “ESR studies of NO free radicals generated from biological system.” In 2001 EPR Visible Systems 9th International Meeting. USA.

4. “Preventive Effects of Green Tea Polyphenols on 6-Hydroxydopamine-Induced Apoptosis in PC12 Cells” In 2001, 1th International Conference on Alzheimers Disease and Related Neurodegenerative Disorders. Wuhan,China.

5. “ESR spin trapping study on NO free radicals generated from wheat stripe rust.” 7th International Symposium on Spin Trapping. Chapel Hill, NC,USA. 2002.

6. Oral administration of Crataegus extraction protects against ischemia/reperfusion brain damage in the Mongolian gerbils. 8th International Symposium on Spin Trapping. Kyushu, Japan 2003。大會主席: Utsumi Hideo.

7．Anti-apoptotic effect of green tea polyphenols on neurons. 4th East Asia Biophysics Symposium. Taipei, 2003.

8. Smoke free radicals and health, scavenging effects of pycnogenol on free radicals generated from cigarette smoke and detoxification effects.. International Symposium on Free radical and Health. Sakata, Japan.2003. 大會主席：Hiramatsu Midori.

9. Antioxidants prevent neurodegenerative diseases. ISN Satellite Meeting:Oxidative Stress in Neurodegenerative Disorder. Guilin China, 2004. 。

10. Genistein ameliorated β-amyloid peptide -induced hippocampal neuronal apoptosis. 9th International Conference on Alzheimers Disease and Related Disorders in Philadelphia, Pennsylvania, USA, July 17-22, 2004. 大會主席：Kerri Leo。

11.  自由基、抗氧化劑與衰老.第六屆全國自由基生物學與自由基醫學學術會議和海峽兩岸自由基生物學與自由基醫學學術會議。2004年9月17~21日，西安。

12. Protective Effects of Natural antioxidants on neurodegenration diseases. The Third International Symposium on Natural Antioxidants- Molecular Mechanisms and Health Effects (ISNA) and Meeting of the Society for Free Radical Research (SFRR Asia), Shanghai, China.Jun 24-29,2005.

13. Why drinking green tea prevents obesity? The 13th Sendai Conference on Lipid Peroxide Biology and Medicine. Sendai, Japan, August 15,2005. 。

14．自由基、抗氧化劑與衰老。中國科學技術協會第七屆學術年會。2005年8月20-23日在新疆烏魯木齊市。

15. “Development of L-band and X-band ESR imaging systems in China” International Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems – (EPR 2005). Colunbus, Ohio USA. September 4-8, 2005.大會主席KUPPUSAMY, PERIANNAN

16. Protective effects of green tea polyphenols against 6-OHDA induced apoptosis throng ROS-NO pathway in parkinson’s disease. Collegium International Neuro-Phychopharmacolocium (CINP) Asia Pacific Regional Meeting. 14-17/3/2006, Pattaya, Thailand.

17. 自由基、抗氧化劑與衰老. 第十次中國生物物理大會暨第八屆會員代表大會. 2006年5月23-27日在青島市.

18. Effects of nicotine on Alzheimer’s disease and Parkinson’s disease. 1st Shanghai Symposium on Tobacco and Health Jun 8-9, 2006, Shanghai, China.

19. The Anti-obesity Effect of Green Tea Polyphenols through a Noval Mechanism of Lipids Oxidation and Antioxidant. 13thBiennial Meeting of the Society for Free Radical Research International. !5-19/8/2006, Davos, Switzerland.